Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes

Figure 3

Uptake rates 1/k derived from the two-compartment model. Boxplots of the maximum DOX fluorescence intensity (a) and the uptake rate 1/k (d) and their corresponding spatial distributions, respectively (b, e). Characteristic examples of fluorescence signal enhancements collected in two nuclei (dark plain curves) and the fitted curves derived from the two-compartment model (dashed red curves) (c, f). Two distinct subpopulations of uptake rates in the FOV (e) are significantly different (g).