Single-Chain Variable Fragment Antibody of Vascular Cell Adhesion Molecule 1 as a Molecular Imaging Probe for Colitis Model Rabbit Investigation

<div>Representative pictures of <sup>99m</sup>Tc-scFv-VCAM-1 SPECT imaging in rabbits. (a) Probe uptake was observed at the left part of the model rabbit abdomen (yellow arrow) and could be blocked by an excessive unlabeled scFv-VCAM-1. The control group showed weak uptake at the corresponding region. (b) The SPECT/CT images located tracer uptake (yellow arrows) in orthogonal slices. The contrast opacification in CT images indicated distal colon location, where the radioactivity accumulated in SPECT images.</div>

Contrast Media & Molecular Imaging

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Figure 3: Single-Chain Variable Fragment Antibody of Vascular Cell Adhesion Molecule 1 as a Molecular Imaging Probe for Colitis Model Rabbit Investigation 

Figure 3 | Single-Chain Variable Fragment Antibody of Vascular Cell Adhesion Molecule 1 as a Molecular Imaging Probe for Colitis Model Rabbit Investigation 