Ability of ¹⁸F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma

Table 2

The results of ROC analysis of potentially optimal texture parameters in PET and CT images for breast lymphoma versus breast carcinoma.

Variable	Lymphoma		Carcinoma		AUC	P value
	Median	Range	Median	Range
Radiomic parameters on PET
HISTO_entropy_log10	1.36	0.64–1.76	0.97	0.32–1.66	0.740	0.001
SHAPE_volume(# vx)	183.00	22.00–6334.00	71.00	11.00–4241.00	0.725	0.002
GLCM_entropy_log10	2.04	1.00–3.19	1.54	0.59–3.03	0.730	0.001
GLRLM_HGRE	287.95	17.14–1919.15	75.66	9.96–862.28	0.752	<0.001
NGLDM_Contrast	0.33	0.04–2.32	0.16	0.00–0.59	0.712	0.003
GLZLM_HGZE	266.62	17.53–1593.64	83.77	9.67–832.22	0.754	<0.001
Radiomic parameters on CT
HISTO_Kurtosis	5.02	1.90–217.17	2.84	1.49–97.34	0.660	0.024
SHAPE_volume (mL)	11.38	1.07–403.07	4.40	0.73–272.41	0.728	0.001
GLCM_Homogeneity	0.49	0.08–0.60	0.44	0.33–0.65	0.628	0.072
GLRLM_RLNU	977.06	135.49–24346.21	507.35	80.31–19527.32	0.685	0.009
NGLDM_Busyness	0.53	0.04–6.04	0.38	0.13–2.77	0.602	0.152
GLZLM_LZHGE	14709543.63	77721.12–1603305720.99	1385779.22	44958.07–435410392.46	0.681	0.011

Abbreviations: HISTO, histogram; GLCM, gray-level co-occurrence matrix; GLRLM, gray-level run-length matrix; HGRE, high gray-level run emphasis; GLZLM, gray-level zone-length matrix; HGZE, high gray-level zone emphasis; RLNU, run-length nonuniformity; LZHGE, long-zone high gray-level emphasis.