Radiosynthesis and Preclinical Evaluation of ¹¹C-VA426, a Cyclooxygenase-2 Selective Ligand

Figure 10

Inhibition study in the peripheral inflammation model; inflammation was induced by intraperitoneal injection of LPS six hours before the study. Mice were treated with celecoxib (n = 3) or vehicle (n = 3) prior ¹¹C-VA426 injection and sacrificed after 10 minutes. Uptake values in peripheral areas are expressed as percentage of injected dose per gram of tissue (%ID/g) ( vs. vehicle).