Radiosynthesis and Preclinical Evaluation of ¹¹C-VA426, a Cyclooxygenase-2 Selective Ligand

Figure 9

PET images of ¹¹C-VA426 distribution in mouse (a) at 10 and (b) 30 minutes after injection. Each acquisition was shown in coronal, transaxial, and sagittal sections, respectively. Mice were anaesthetized with a mixture of 2% isoflurane in air, injected intravenously with 1.85 MBq (mouse 1) and 3.7 MBq (mouse 2) of ¹¹C-VA426 and, respectively, pretreated (5 min before) with celecoxib or vehicle (DMSO). Dynamic PET data were acquired for 30 minutes (four scans of 2.5 minutes followed by four of 5 minutes). White arrow indicates the main anatomical regions of ¹¹C-VA426 distribution. In coronal views, R (right) and L (left) indicate the spatial orientation of mouse.

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