Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models

Table 1

Summary of the molecular preclinical imaging techniques used with regard to personalized medicine. The columns define the techniques, tracers, and cell lines used to model human breast cancer, specific receptor targets, and therapies.

Imaging	Tracer	Cell line	Receptor	Treatment	Reference
PET	^18F-FBEM-ZHER2:342	MDA-MB-361	HER2	17-DMAG	[16, 17]
		MCF7
		MDA-MB-468
		MCF7/clone18
		BT474
PET	^18F-FBEM-HER2:342	BT474	HER2	Trastuzumab	[18]
NIR; PET	700 Annexin-V	BT474-AZ MMTV/HER2	HER2	Trastuzumab	[19]
	18F-FDG
	18F-FLT
MRI; (DW–DCE)		BT474	HER2	Trastuzumab	[20]
		HR6
PET–MRI	^18F-FLT	BT474	HER2	Trastuzumab	[21]
		HR6
NIR; PET	700 Annexin-V	MMTV/HER2+	HER2	Trastuzumab; Rapamycin	[22]
	^18F-FDG
NIR	QD-PEG	SKBR-3	HER2		[23]
	QD-4D5scFv
HFUS	Anti-VEGFR2-MBs	67NR	VEGFR2		[24]
PET	^18F-FES	SSM2	ERα–PR	Fulvestrant	[25]
	^18F-FFNP	SSM3