Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design

<div>Normalized tumor volume for each group of mice in the pretargeted huA33-TCO/<sup>177</sup>Lu-DOTA-PEG<sub>7</sub>-Tz radioimmunotherapy study. The two control groups received either huA33-TCO (blue) or Tz radioligand (red) only. The three treatment groups received huA33-TCO followed 24 h later by 18.5 (green), 37.0 (purple), or 55.5 (orange) MBq of <sup>177</sup>Lu-DOTA-PEG<sub>7</sub>-Tz. Striking differences were observed between treatment and control groups [<a href="/journals/cmmi/2019/9182476/#B40">40</a>].</div>

Contrast Media & Molecular Imaging

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Figure 3: Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design 

Figure 3 | Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design 