Review Article

Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design

Table 2

Comparison of the molecular net charge and the primary elimination route for different radiolabeled Tz derivatives.

Radiolabeled Tz derivativesMolecular net chargePrimary elimination route

Al[18F]-NODA-Tz0Hepatic and intestinal excretion
68Ga-NODA-Tz+1Renal excretion
Al[18F]-NOTA-lysine-Tz0Hepatic and intestinal excretion
Al[18F]-NOTA-(lysine)2-Tz+1Renal excretion
Al[18F]-NOTA-(lysine)3-Tz+2Renal excretion
64Cu-NOTA-Tz−1Hepatic and intestinal excretion
64Cu-NOTA-PEG7-Tz−1Hepatic and intestinal excretion
64Cu-SarAr-Tz+2Renal excretion