Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!

Table 1

Quantification of [¹¹C]PIB uptake in ipsilateral (LPC) and contralateral (SAL) regions of interest (ROI) manually drawn onto T2WI (as shown in Figure 1(a)). The LPC-to-SAL ratio is expected to be < 1 in case of demyelination.

Rat	MRI observations	Vol. (mm^3) of ROI on T2WI	[^11C]PIB uptake (%ID/g)
			LPC	SAL	Ratio
A	Large demyelination	5.20	0.16	0.15	1.03
B	Large demyelination	3.70	0.53	0.47	1.12
C	Small demyelination with necrosis	2.20	0.25	0.29	0.88
D	Small demyelination with ventricle dilation	1.90	0.23	0.23	1.00