Distinguishing Lymphomatous and Cancerous Lymph Nodes in 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography by Radiomics Analysis
Table 5
The differentiating ability of each predictive variable in cross-validation (training set and test set).
In training set
Predictive variables
AUC
Cutoff point
Sensitivity (%)
Specificity (%)
Accuracy (%)
LLN versus CLN
SUVmax
0.74
10.40
84.52
61.45
72.46
<0.01
PREct
0.92
0.35
95.24
83.13
89.22
<0.01
PREpet
0.90
0.42
82.14
85.54
83.83
<0.01
PREcombination
0.96
0.39
92.86
93.98
92.81
<0.01
HLLN versus CLN
SUVmax
0.72
7.16
79.07
58.54
65.62
<0.01
PREct
0.95
0.33
88.37
98.78
95.24
<0.01
PREpet
0.90
0.63
79.07
85.37
85.67
<0.01
PREcombination
0.98
0.62
97.67
98.78
96.83
<0.01
NHLLN versus CLN
SUVmax
0.71
10.40
85.54
53.01
69.28
<0.01
PREct
0.90
0.41
95.18
83.13
88.55
<0.01
PREpet
0.86
0.47
84.34
78.31
80.72
<0.01
PREcombination
0.96
0.28
87.95
92.77
89.16
<0.01
HLLN versus NHLLN
SUVmax
0.52
11.20
46.99
63.41
55.15
>0.05
PREct
0.79
0.36
81.93
70.73
74.19
<0.01
PREpet
0.79
0.41
81.93
65.85
79.03
<0.01
PREcombination
0.86
0.51
92.77
68.29
83.87
<0.01
In test set
LLN versus CLN
SUVmax
0.67
10.40
80.56
37.14
59.15
<0.01
PREct
0.96
0.35
88.89
91.43
90.14
<0.01
PREpet
0.87
0.42
77.78
71.43
74.65
<0.01
PREcombination
0.95
0.39
91.67
94.29
92.96
<0.01
HLLN versus CLN
SUVmax
0.65
7.16
72.22
52.78
59.26
<0.05
PREct
0.83
0.33
66.67
97.22
87.04
<0.01
PREpet
0.76
0.63
61.11
75.00
70.37
<0.01
PREcombination
0.85
0.62
77.78
97.22
90.74
<0.01
NHLLN versus CLN
SUVmax
0.70
10.40
82.86
47.22
64.79
<0.01
PREct
0.84
0.41
97.14
75.00
85.92
<0.01
PREpet
0.88
0.47
80.00
75.00
77.46
<0.01
PREcombination
0.90
0.28
77.14
88.89
83.10
<0.01
HLLN versus NHLLN
SUVmax
0.57
11.20
47.22
76.47
56.60
>0.05
PREct
0.74
0.36
72.22
52.94
66.04
<0.01
PREpet
0.72
0.41
80.56
58.82
73.58
<0.01
PREcombination
0.78
0.51
88.89
52.94
77.36
<0.01
The cutoff point in the training set is consistent with that in the verification set. Abbreviations: AUC, area under the ROC curve; ROC, receiver operating characteristics; SUV, standardized uptake value; LLN, lymphomatous-lymph nodes; CLN, cancerous-lymph nodes; HLLN, LLN caused by Hodgkin’s lymphoma; NHLLN, LLN caused by non-Hodgkin lymphoma; PREct, CT-predictive variables; PREpet, PET-predictive variables, PREcombination, the combination of PET and CT predictive variables.
