Molecular Magnetic Resonance Imaging with Contrast Agents for Assessment of Inflammatory Bowel Disease: A Systematic Review

Figure 3

The absorption pathway of SLN. Lymphatic circulation plays an important role in SLN absorption [25]. Typically, most SLNs are either taken up by the M-cells overlying the lymphoid follicles, Peyer’s patches, and circumambient lymphatic drainage, or transported via capillaries in direct or paracellular pathways [26–28]. However, in pathological situations, SLNs are primarily absorbed into the submucosal capillary network through the impaired colorectal mucosa. Furthermore, PEG-modified nanoparticles were more inclined to deposit at this lesion.