Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice

Figure 2

Chronological changes of GluCEST effects in 5xFAD and WT mice in the same ROIs as in T2WI images from Figure 1. GluCEST effect was significant at 4 months of age (parietal and temporal cortex, hippocampus) to 7 months of age (frontal cortex), except in the striatum and thalamus, where a decrease was observed by 10 months of age. In WT mice, a focal decrease (parietal cortex and hippocampus) in GluCEST effects became prominent only at 15 months of age. The number in parentheses indicates the number of analyzed mice. , compared with 1-month-old mice. ^†p > 0.05, ^††p > 0.01 compared with WT mice.

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