Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice

<div>GluCEST effect, Ficvf derived from NODDI, and syntrophin concentration in 7-month-old mice. (a) Representative images of 7-month-old 5xFAD and WT mice showing reduction in both GluCEST effects and Ficvf values in the parietal cortex and hippocampus. (b) ROI Ficvf showing significant reduction in the parietal cortex and hippocampus. (c) Correlation between GluCEST effects and Ficvf showing no correlation in the hippocampus, whereas there is a significant correlation between Ficvf and GluCEST in the parietal cortex. 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Contrast Media & Molecular Imaging

fig6

Figure 6

Figure 6: Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice 