Application of Distributed Parameter Model to Assessment of Glioma IDH Mutation Status by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Table 1

Median value and interquartile range (i.e., range between the 25^th and the 75^th percentile, in parentheses) of kinetic parameters of two tracer kinetic models in IDH-mutant gliomas and IDH-wildtype gliomas and the results of the Wilcoxon test.

Model	Parameters	IDH-mutant (n = 24)	IDH-wildtype (n = 31)	value
Tofts	K^trans (min^−1)	0.02 (0.01–0.10)	0.07 (0.04–0.09)	0.013
	Ve (mL/100 mL)	0.24 (0.00–8.65)	10.01 (7.86–16.10)	<0.001
	Kep (min^−1)	0.67 (0.28–70.53)	0.49 (0.35–1.00)	0.525
DP	F (mL/min/100 mL)	9.21 (4.70–12.82)	12.48 (10.04–14.56)	0.018
	PS (mL/min/100 mL)	0.21 (0.03–1.52)	3.38 (2.41–5.74)	<0.001
	E (%)	1.36 (0.50–10.86)	23.10 (16.05–36.99)	<0.001
	Ve (mL/100 mL)	0.25 (0.12–9.91)	9.30 (5.69–15.11)	0.002
	Vp (mL/100 mL)	0.21 (0.06–0.44)	1.59 (0.93–2.43)	<0.001