Application of Distributed Parameter Model to Assessment of Glioma IDH Mutation Status by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Table 2

Diagnostic performance of kinetic parameters of two tracer kinetic models in distinguishing IDH-mutant from IDH-wildtype gliomas.

Model	Parameters	AUC	Cutoff value	Sensitivity (%)	Specificity (%)	Accuracy (%)
Tofts	K^trans (min^−1)	0.69	0.02	50.0	96.8	72.7
	Ve (mL/100 mL)	0.79	2.81	66.7	87.1	78.2
	Kep (min^−1)	0.55	0.40	37.5	67.7	67.3
DP	F (mL/min/100 mL)	0.69	6.08	37.5	100.0	63.6
	PS (mL/min/100 mL)	0.81	2.30	83.3	77.4	80.0
	E (%)	0.80	5.98	70.8	90.3	81.8
	Ve (mL/100 mL)	0.75	2.03	62.5	90.3	78.2
	Vp (mL/100 mL)	0.92	0.74	87.5	80.7	83.6