Radiomic Features of 18F-FDG PET in Hodgkin Lymphoma Are Predictive of Outcomes
Table 3
Univariate and multivariate analyses for prognostic factors of PFS.
Features
value
HR (95% CI)
Univariate analysis
Clinical parameters
Gender
0.1726
2.579 (0.6609–10.06)
Age (>30)
0.2104
0.4514 (0.1300–1.567)
Ann Arbor stage
0.0590
3.394 (0.9548–12.07)
Extranodal sites
0.1788
2.398 (0.6700–8.581)
B symptoms
0.2791
2.067 (0.5550–7.698)
BM
0.0213
9.985 (1.363–46.78)
Bulky disease (>10 cm)
0.2886
3.078 (0.3859–24.55)
Dmax
0.0002
34.78 (5.206–232.4)
Chemotherapy with IFRT
0.0908
8.589 (0.7105–103.8)
PET variables
SUVmax
0.0723
10.52 (0.8081–137.0)
MTV
0.0016
9.811 (2.371–40.59)
SUV kurtosis
0.0316
3.961 (1.129–13.90)
LZHGEGLZLM
0.0013
8.036 (2.258–28.60)
Multivariable analysis
BM
0.086
—
Dmax
0.048
3.641 (1.011–13.110)
MTV
0.618
—
SUV kurtosis
0.243
—
LZHGEGLZLM
0.044
9.007 (1.066–76.116)
Statistically significant. HR, hazard ratio; CI, confidence interval; LDH, lactate dehydrogenase; BM, bone marrow; Dmax, the distance between the two lesions that were the furthest apart; MTV, metabolic tumor volume; LZHGE, long-zone high gray-level emphasis; GLZLM, gray-level zone-length matrix.
