Change of Apoptosis and Glucose Metabolism in Lung Cancer Xenografts during Cytotoxic and Anti-Angiogenic Therapy Assessed by Annexin V Based Optical Imaging and <sup>18</sup>F-FDG-PET/CT

<div>Overview of the study design. Five groups of lung cancer xenograft (A549) bearing mice were investigated: (i) untreated controls and treated groups after (ii) anti-angiogenic (SU11248) or (iii) cytotoxic (carboplatin) treatment for four and nine days. Optical imaging of apoptosis using an Annexin V-based probe was performed with FMT/<i>µ</i>CT, followed by <sup>18</sup>F-FDG-PET/CT. Imaging data were validated by quantitative immunohistochemistry.</div>

Contrast Media & Molecular Imaging

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Figure 1: Change of Apoptosis and Glucose Metabolism in Lung Cancer Xenografts during Cytotoxic and Anti-Angiogenic Therapy Assessed by Annexin V Based Optical Imaging and <sup>18</sup>F-FDG-PET/CT 

Figure 1 | Change of Apoptosis and Glucose Metabolism in Lung Cancer Xenografts during Cytotoxic and Anti-Angiogenic Therapy Assessed by Annexin V Based Optical Imaging and 18F-FDG-PET/CT 