Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on ¹⁸F-FDG PET/CT for Patients with Colorectal Cancer

Table 4

Univariate and multivariate Cox regression analyses (palliative treatment).

Variables	PFS						OS
	Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value
Age	0.99	0.97–1.01	0.347				1.02	0.97–1.06	0.502
Gender
Male	1.00						1.00
Female	1.51	0.80–2.83	0.200				1.35	0.46–3.90	0.586
Tumor location
Right colon	1.00						1.00
Left colon	0.88	0.43–1.79	0.724				0.45	0.15–1.39	0.167
Rectum	0.67	0.28–1.63	0.379				0.18	0.02–1.42	0.102
Pathological types
Adenocarcinoma	1.00						1.00
MAC/SRC	0.80	0.24–2.61	0.71				1.76	0.38–8.08	0.470
Differentiation
LD	1.00						1.00
MD/HD	1.17	0.54–2.55	0.687				0.61	0.20–1.82	0.372
Tumor diameter	1.13	0.91–1.39	0.280				1.38	0.99–1.93	0.059
T stage
T1-2	1.00						1.00
T3-4	2.94	0.40–21.60	0.289				-	-	-
Regional lymph nodes
N−	1.00						1.00
N+	2.05	0.86–4.91	0.106				1.66	0.37–7.44	0.511
Nerve invasion
Negative	1.00						1.00
Positive	1.13	0.60–2.14	0.696				1.32	0.46–3.82	0.607
Tumor thrombus
Negative	1.00						1.00
Positive	1.80	0.96–3.36	0.067				2.55	0.85–7.65	0.095
CEA (ng/ml)
Normal (≤5.00)	1.00						1.00
Increased (>5.00)	1.47	0.61–3.52	0.388				1.83	0.40–8.40	0.436
CA19-9 (U/ml)
Normal (≤37.00)	1.00						1.00
Increased (>37.00)	1.44	0.77–2.70	0.251				2.50	0.83–7.47	0.102
SUVmax	1.04	1.00–1.08	0.063				1.02	0.94–1.09	0.683
SUVmean	1.07	1.00–1.14	0.062				1.02	0.89–1.15	0.825
SUVpeak	1.07	1.01–1.13	0.025	1.04	0.97–1.11	0.318	1.02	0.92–1.13	0.710
MTV (ml)	1.01	1.00–1.03	0.075				1.00	0.99–1.03	0.530
TLG (g)	1.00	0.99–1.00	0.012	1.00	1.00–1.00	0.712	1.00	0.99–1.00	0.502
HI-1
≤0.23	1.00						1.00
>0.23	0.57	0.29–1.12	0.103				0.66	0.20–2.13	0.485
HI-2	1.04	1.02–1.07	0.001	1.03	1.01–1.06	0.020	1.03	1.00–1.06	0.061

PFS, progression-free survival; OS, overall survival; MAC, mucinous adenocarcinoma; SRC, signet ring cell carcinoma; LD, low-differentiation; MD, middifferentiation; HD, high-differentiation; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; SUV, standardized uptake value; MTV, metabolic tumor volume; TLG, total lesion glycolysis; HI, heterogeneity index. Bold values, P < 0.05.