Preparation, Characterization, and Preliminary Imaging Study of [¹⁸⁸Re]Re-Ibandronate as a Novel Theranostic Radiopharmaceutical for Bone Metastasis

Table 2

The biodistribution of [¹⁸⁸Re]Re-IBA in mice (n = 4).

Tissue	%ID/g (%)
	1 h	3 h	6 h	24 h	48 h
Heart	0.488 ± 0.179	0.293 ± 0.118	0.199 ± 0.049	0.045 ± 0.012	0.019 ± 0.010
Liver	1.100 ± 0.165	0.794 ± 0.133	0.526 ± 0.087	0.122 ± 0.042	0.038 ± 0.020
Spleen	0.952 ± 0.336	0.475 ± 0.135	0.296 ± 0.108	0.189 ± 0.052	0.046 ± 0.009
Lung	1.297 ± 0.661	0.784 ± 0.196	0.506 ± 0.104	0.138 ± 0.037	0.040 ± 0.020
Kidney	5.894 ± 1.648	3.140 ± 0.799	2.763 ± 0.731	0.913 ± 0.173	0.399 ± 0.153
Stomach	2.928 ± 0.851	2.801 ± 0.560	1.741 ± 0.368	0.098 ± 0.036	0.047 ± 0.019
Thyroid gland	0.594 ± 0.201	0.449 ± 0.171	0.399 ± 0.082	0.115 ± 0.036	0.070 ± 0.019
Small intestine	0.898 ± 0.494	0.597 ± 0.214	0.608 ± 0.192	0.078 ± 0.013	0.033 ± 0.010
Blood	1.869 ± 0.665	0.785 ± 0.220	0.496 ± 0.207	0.058 ± 0.013	0.031 ± 0.009
Brain	0.072 ± 0.023	0.056 ± 0.010	0.045 ± 0.011	0.024 ± 0.013	0.009 ± 0.002
Femur	5.989 ± 1.680	7.105 ± 1.901	7.724 ± 2.292	6.177 ± 2.163	5.239 ± 2.029
Muscle	0.550 ± 0.251	0.344 ± 0.143	0.220 ± 0.124	0.051 ± 0.020	0.016 ± 0.005
Gonad	0.878 ± 0.426	0.611 ± 0.095	0.303 ± 0.141	0.059 ± 0.032	0.029 ± 0.009
Femur/heart	12.278	24.214	38.835	137.083	270.814
Femur/liver	5.443	8.949	14.694	50.645	136.914
Femur/muscle	10.880	20.664	35.182	121.910	325.483

The percentage injection dose rate per gram of tissue (%ID/g) is expressed as mean ± standard deviation ( ± s).