Preparation, Characterization, and Preliminary Imaging Study of [¹⁸⁸Re]Re-Ibandronate as a Novel Theranostic Radiopharmaceutical for Bone Metastasis

Table 3

The biodistribution of [¹⁸⁸Re]ReO₄^- in mice (n = 4).

Tissue	%ID/g (%)
	1 h	3 h	6 h	24 h	48 h
Heart	1.422 ± 0.339	0.401 ± 0.050	0.176 ± 0.074	0.017 ± 0.005	0.011 ± 0.004
Liver	2.480 ± 0.556	0.530 ± 0.038	0.258 ± 0.086	0.023 ± 0.010	0.018 ± 0.010
Spleen	2.341 ± 0.973	0.490 ± 0.090	0.270 ± 0.098	0.028 ± 0.007	0.022 ± 0.006
Lung	4.458 ± 1.379	1.026 ± 0.312	0.487 ± 0.132	0.054 ± 0.017	0.036 ± 0.008
Kidney	2.923 ± 0.658	0.683 ± 0.118	0.338 ± 0.191	0.017 ± 0.003	0.017 ± 0.007
Stomach	22.747 ± 5.67	8.578 ± 3.928	2.828 ± 1.287	0.053 ± 0.032	0.029 ± 0.012
Thyroid gland	20.247 ± 2.489	10.167 ± 1.618	4.299 ± 1.015	0.051 ± 0.026	0.025 ± 0.009
Small intestine	1.671 ± 0.448	0.558 ± 0.207	0.263 ± 0.050	0.023 ± 0.004	0.014 ± 0.005
Blood	4.648 ± 1.631	1.578 ± 0.419	0.533 ± 0.254	0.023 ± 0.009	0.007 ± 0.002
Brain	0.207 ± 0.044	0.070 ± 0.024	0.044 ± 0.019	0.017 ± 0.004	0.013 ± 0.006
Femur	1.670 ± 0.345	0.431 ± 0.038	0.213 ± 0.102	0.031 ± 0.003	0.011 ± 0.005
Muscle	0.775 ± 0.074	0.182 ± 0.023	0.109 ± 0.065	0.021 ± 0.008	0.020 ± 0.005
Gonad	1.096 ± 0.007	0.404 ± 0.130	0.207 ± 0.065	0.021 ± 0.009	0.007 ± 0.001
Femur/heart	1.195	1.075	1.205	1.853	1.060
Femur/liver	0.685	0.813	0.823	1.325	0.638
Femur/muscle	2.193	2.372	1.950	1.498	0.585

The percentage injection dose rate per gram of tissue (%ID/g) is expressed as mean ± standard deviation ( ± s).