Preparation, Characterization, and Preliminary Imaging Study of [¹⁸⁸Re]Re-Ibandronate as a Novel Theranostic Radiopharmaceutical for Bone Metastasis

Table 4

The biodistribution of [¹⁸⁸Re]Re-IBA in nude mice of bone metastasis model (n = 4).

Tissue	%ID/g (%)
	1 h	3 h	6 h	24 h	48 h
Heart	0.595 ± 0.099	0.326 ± 0.175	0.183 ± 0.097	0.052 ± 0.027	0.035 ± 0.013
Liver	1.236 ± 0.219	0.431 ± 0.312	0.368 ± 0.054	0.089 ± 0.027	0.044 ± 0.013
Spleen	0.530 ± 0.124	0.227 ± 0.141	0.176 ± 0.029	0.066 ± 0.024	0.022 ± 0.013
Lung	1.135 ± 0.209	0.298 ± 0.250	0.257 ± 0.030	0.101 ± 0.038	0.047 ± 0.005
Kidney	6.004 ± 0.523	2.591 ± 1.120	2.587 ± 0.126	0.640 ± 0.175	0.121 ± 0.034
Stomach	3.056 ± 0.321	2.064 ± 0.207	1.176 ± 0.190	0.192 ± 0.092	0.027 ± 0.019
Thyroid gland	0.625 ± 0.309	0.282 ± 0.149	0.354 ± 0.217	0.082 ± 0.030	0.020 ± 0.010
Small intestine	0.718 ± 0.073	0.404 ± 0.047	0.242 ± 0.118	0.049 ± 0.003	0.030 ± 0.018
Blood	1.704 ± 0.348	0.531 ± 0.092	0.302 ± 0.092	0.045 ± 0.020	0.021 ± 0.008
Brain	0.098 ± 0.046	0.082 ± 0.017	0.042 ± 0.042	0.037 ± 0.020	0.021 ± 0.009
CB	9.331 ± 0.541	7.717 ± 4.349	7.662 ± 2.934	4.413 ± 2.225	4.737 ± 0.863
MB	8.329 ± 0.329	5.922 ± 2.126	8.417 ± 1.820	6.403 ± 0.247	6.503 ± 0.010
CS	0.578 ± 0.043	0.524 ± 0.172	0.153 ± 0.083	0.081 ± 0.050	0.041 ± 0.022
Gonad	0.439 ± 0.162	0.231 ± 0.068	0.106 ± 0.022	0.069 ± 0.018	0.028 ± 0.001
CB/heart	15.682	23.637	41.876	85.157	133.599
CB/liver	7.549	17.896	20.818	49.848	106.617
CB/CS	16.144	14.731	50.044	54.620	115.161
MB/heart	14.003	18.139	45.999	123.563	183.399
MB/liver	6.738	13.734	22.867	72.330	146.359
MB/CS	14.411	11.305	54.970	79.255	158.088
MB/CB	0.893	0.767	1.099	1.451	1.373

The percentage injection dose rate per gram of tissue (%ID/g) is expressed as mean ± standard deviation ( ± s). CB, contralateral bone; MB, model bone; CS, contralateral muscle.