The Efficacy of Combined Therapy of Regorafenib with Detoxicating and Stasis Softening Chinese Herbal Spleen Tonics in Mid-/Late-Stage Hepatocellular Carcinoma

<div>Synergistic effect of combining regorafenib and DSS-splenic tonics. (a). Weight change of HCCLM3 xenograft nude mice model treated with regorafenib (a), DSS-splenic tonics (b), Regorafenib + DSS-splenic tonics (c) and control; (b). Changes of subcutaneous tumor of HCCLM3 xenograft nude mice model treated with regorafenib and/or DSS-splenic tonics; (c). Size of primary tumor of HCCLM3 xenograft nude mice model treated with regorafenib and/or DSS-splenic tonics; (d) Lung metastasis of HCCLM3 xenograft nude mice model treated with regorafenib (REG), DSS-splenic tonics (DSS), Regorafenib + DSS-splenic tonics (REG-DSS) and control. DSS-spleen tonics downregulates VEGF, HIF-1<i>α</i>, VEGF-2 and MVD.</div>

Contrast Media & Molecular Imaging

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Figure 2: The Efficacy of Combined Therapy of Regorafenib with Detoxicating and Stasis Softening Chinese Herbal Spleen Tonics in Mid-/Late-Stage Hepatocellular Carcinoma 

Figure 2 | The Efficacy of Combined Therapy of Regorafenib with Detoxicating and Stasis Softening Chinese Herbal Spleen Tonics in Mid-/Late-Stage Hepatocellular Carcinoma 