The Efficacy of Combined Therapy of Regorafenib with Detoxicating and Stasis Softening Chinese Herbal Spleen Tonics in Mid-/Late-Stage Hepatocellular Carcinoma

Table 2

Adverse events.

	REG	REG-DSS	-value
Diarrhea	28	30	0.9983
Fatigue	30	33
Palmar-plantar erythrodysesthesia	40	32
Elevated serum aspartate aminotransferase	28	27
Elevated serum blood bilirubin	8	9
Elevated serum amylase	9	10
Hypoalbuminemia	18	16
Hypertension	25	28
Erythema multiforme	19	21
Anemia	16	17
Decreased platelet count	10	11

Combined therapy of Regorafenib with DSS-spleen tonics achieved better efficacy in mid-/late-stage HCC.