The Combination of 18F-Fluorodeoxyglucose Positron Emission Tomography Metabolic and Clinical Parameters Can Effectively Distinguish Rheumatoid Arthritis and Polymyalgia Rheumatic
Table 3
Differential diagnostic efficiency of SUVmax and qualitative scores (mean reference score compared to control) and clinical parameters with receiver operating characteristic analysis.
Variable
AUC
P value
Sen (%)
Spe (%)
PPV
NPV
SUVmax
Interspinous ligament
0.764
0.001
64.5
78.3
0.800
0.621
Sacroiliac joint
0.705
0.010
48.4
82.6
0.789
0.542
Hip joint
0.664
0.041
51.6
82.6
0.800
0.559
Trochanter
0.718
0.007
71.0
65.2
0.733
0.625
Ischial tubercle
0.753
0.002
83.9
56.5
0.722
0.722
Combination
0.832
<0.001
90.3
69.6
0.800
0.842
Mean ref. (control) score cases
Interspinous ligament
0.712
0.008
83.9
56.5
0.722
0.722
Sacroiliac joint
0.658
0.048
67.7
60.9
0.700
0.583
Trochanter
0.663
0.042
51.6
82.6
0.800
0.559
Symphysis pubis
0.671
0.033
90.3
34.8
0.651
0.727
Ischial tubercle
0.730
0.004
83.9
56.5
0.722
0.722
Combination
0.794
<0.001
90.3
60.9
0.757
0.824
Clinical parameters
RF positive
0.788
<0.001
96.8
60.9
0.769
0.933
AKA positive
0.717
0.007
100.0
43.5
1.000
0.705
anti-CCP Ab positive
0.794
<0.001
93.5
65.2
0.784
0.882
AUC: area under curve; SUV max: maximum standardized uptake value; Sen: sensitivity; Spe: specificity; PPV: positive predictive value; NPV: negative predictive value; RF: rheumatoid factor; anti-CCP Ab: anti-cyclic citrullinated peptide antibody.
