[Retracted] Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and Bioinformatics
Table 2
Pathway enrichment analysis of hub genes associated with CRC progression.
Biological pathway
No. of genes in the dataset
Fold enrichment
P-value
Genes mapped
Epithelial-to-mesenchymal transition
4
6.489
0.002928
AP1S2, ZCCHC24, VIM, SPARC
Sphingolipid metabolism
2
20.743
0.004083
PPM1L, ACER2
Intrinsic pathway for apoptosis
2
19.405
0.004657
VIM, BCL2
FGFR2c ligand binding and activation
1
150.436
0.006667
FGFR2
Asparagine degradation I
1
150.436
0.006667
ASRGL1
BH3-only proteins associate with and inactivate antiapoptotic BCL2 members
1
100.457
0.009984
BCL2
Caspase cascade in apoptosis
2
11.570
0.012733
VIM, BCL2
ATF2 transcription factor network
2
10.198
0.016201
BCL2, PPARGC1A
CREB phosphorylation through the activation of adenylate cyclase
1
60.354
0.016587
PRKACB
Activation, myristoylation of BID, and translocation to mitochondria
