Macromolecular imaging is a developing discipline focused on the creation of new imaging probes and biomarkers that may be used to observe molecular and cellular processes non-invasively. This Special Issue focuses on macromolecular imaging in the context of radiation research, with a focus on biomarkers and imaging methods that provide measurable signals that can aid in the quantification of radiation-induced effects on living systems at the physical, chemical, and biological levels. The ability to visualise molecular alterations in response to a radiation insult opens up new and intriguing avenues for a more in-depth study of radiation biology, with the prospect of translating these approaches into radiotherapy treatment.

This Special Issue is devoted to the application of macro-molecular imaging in radiation research. Over the last decade, macro molecular imaging contributed significantly to new breakthroughs in radiation biology. This Special Issue will inspire many researchers to participate in the dynamic future of our profession, armed with these new macromolecular imaging capabilities in relation to radiation biology by producing original research and review articles.

Potential topics include but are not limited to the following:

• Macromolecular imaging and radiotherapy
• Macromolecular imaging and magnetic resonance
• Nuclear and optical Imaging
• Hypoxia and perfusion image identification
• Tissue metabolism, tissue injury and image processing
• Cell death and viability detection
• Biomolecules and molecular imaging
• Receptor targeting and nanotechnology
• Bio-polymers and macrocycles
• Reporter genes and reactive oxygen species (ROS)
• Biological dosimetry and molecular imaging