Organic electronic materials (OEMs) are extremely versatile and have a vast array of applications in modern electronic devices. Organic electronics, such as organic light-emitting diodes (OLEDs), organic transistors, or organic sensors, have been developed for medical applications. Optical sensors are pervasive components in electronic devices and are widely used in healthcare for accurate analysis, disease detection, and monitoring in long-term equipment to protect health and safety. When employed in cutting-edge device configurations for use in biosensing, the unique material properties of organic electronic materials can help greatly to solve major issues. Optical biosensors have considerable promise in the diagnosis of different types of cancer and can help meet the healthcare industry's need for reliable, precise, and efficient medical devices and the crucial tools that contribute to their functionality.

Despite significant technological developments, early cancer detection remains a challenge, and current cancer detection techniques are expensive, uncomfortable, complex, and time-consuming. Developments in organic electronic materials with optical imaging modalities, enhanced design of diverse optical biosensors, optical properties, and biocompatibility are promising techniques for the early detection of cancer and other diseases. Modern optical imaging methods integrate with the development of ultrasound, magnetic resonance imaging (MRI), positron emission tomography (PET), and computed tomography (CT) for improved cancer diagnosis and therapy to help screen patients more precisely. Advances in organic electronics or optical biosensors aid the differentiation between cancer and healthy cells and the remodeling point-of-care devices to be better utilized in cancer diagnostics.

The aim of this Special Issue is to gather research on the application in complex environments of organic electronic materials in optical sensor-based cancer detection, combined with evolving technology, to elevate cancer research to the next level. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

• Optical molecular imaging and sensing for the detection and treatment of advanced cancer
• Organic nanomaterials in optical sensors for better cancer diagnosis
• Diffuse optical tomography (DOT) and diffuse optical imaging (DOI) techniques for cancer imaging
• Novel organic electronic materials in optical imaging with MRI, CT, and PET for more accurate cancer screening
• 3D organic electronic architectures and optical biosensors for detecting cancer biomarkers and risk factors
• Hypersensitive and organic field-effect transistors for reliable biosensing applications in early cancer diagnosis
• Application of multipurpose metal-organic framework (MOF) heterostructures and magnifying composite properties for clinical treatments for cancer
• Efficient optical cytosensor applications for detecting metastatic breast cancer cells or circulating tumor cells (CTCs)
• Design of chip-based optical sensors for personalized diagnosis and reducing terminal stage cancer detection
• Photoacoustic imaging (PAI) and other optical imaging techniques for multispectral analysis of cancer
• Real-time monitoring of cancer based on organic light-emitting diodes and phototherapeutic applications for disease prevention