Livio Mallucci, Valerie Wells, "Negative Control of Cell Proliferation. Growth Arrest versus Apoptosis. Role of βGBP", Computational and Mathematical Methods in Medicine, vol. 1, Article ID 724216, 5 pages, 1998. https://doi.org/10.1080/10273669808833017
Negative Control of Cell Proliferation. Growth Arrest versus Apoptosis. Role of βGBP
βGBP is a novel physiological negative growth regulator of the cell and a cytostatic factor.It is secreted by cells, and bybinding with high affinity to specific cell surface receptors. In normal cell surface receptors. In normal cells, βGBP physiologically controls transition from G0 to G1 and passage from late S phase to G2 by modulating signalling cascades activated by tyrosine Kinase receptors and by affecting transcription events.As a cytostatic Factor βGBP has a marked growth inhibitory effect on a variety of tumours including leukaemias where growth arrest is followed by the activation of apoptotic pathways and cell death.
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