Computational and Mathematical Methods in Medicine

Computational and Mathematical Methods in Medicine / 2007 / Article

Original Article | Open Access

Volume 8 |Article ID 289351 | https://doi.org/10.1080/17486700701303143

Katarzyna A. Rejniak, Robert H. Dillon, "A Single Cell-Based Model of the Ductal Tumour Microarchitecture", Computational and Mathematical Methods in Medicine, vol. 8, Article ID 289351, 19 pages, 2007. https://doi.org/10.1080/17486700701303143

A Single Cell-Based Model of the Ductal Tumour Microarchitecture

Received21 Aug 2006
Revised11 Feb 2007
Accepted16 Feb 2007

Abstract

The preinvasive intraductal tumours, such as the breast or prostate carcinomas, develop in many different architectural forms. There are, however, no experimental models explaining why cancer cells grow in these various configurations. We use a mathematical model to compare different proliferative conditions that can lead to such distinct microarchitectures. In order to simulate different scenarios of tumour growth, we employed a single cell-based technique that allows us to model development of the whole tumour tissue by focusing on biomechanical processes of individual cells and on communication between cells and their microenvironment. Formation of four specific intraductal tumour patterns, micropapillary, cribriform, tufting and solid, are presented in this paper together with a discussion on gradual dedifferentiation of ductal epithelial cells that gives rise to these distinct carcinomas. We introduce two versions of our cell-based model to show that the obtained results do not depend on a particularly chosen cell structure.

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views117
Downloads568
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.