Computational and Mathematical Methods in Medicine

Computational and Mathematical Methods in Medicine / 2010 / Article

Original Article | Open Access

Volume 11 |Article ID 391583 |

D. C. Trost, E. A. Overman, J. H. Ostroff, W. Xiong, P. March, "A Model for Liver Homeostasis Using Modified Mean-Reverting Ornstein–Uhlenbeck Process", Computational and Mathematical Methods in Medicine, vol. 11, Article ID 391583, 21 pages, 2010.

A Model for Liver Homeostasis Using Modified Mean-Reverting Ornstein–Uhlenbeck Process

Received14 Aug 2008
Accepted13 Nov 2008


Short of a liver biopsy, hepatic disease and drug-induced liver injury are diagnosed and classified from clinical findings, especially laboratory results. It was hypothesized that a healthy hepatic dynamic equilibrium might be modelled by an Ornstein–Uhlenbeck (OU) stochastic process, which might lead to more sensitive and specific diagnostic criteria. Using pooled data from healthy volunteers in pharmaceutical clinical trials, this model was applied using maximum likelihood (ML) methods. It was found that the exponent of the autocorrelation function was proportional to the square root of time rather than time itself, as predicted by the OU model. This finding suggests a stronger autocorrelation than expected and may have important implications regarding the use of laboratory testing in clinical diagnosis, in clinical trial design, and in monitoring drug safety. Besides rejecting the OU hypothesis for liver test homeostasis, this paper presents ML estimates for the multivariate Gaussian distribution for healthy adult males. This work forms the basis for a new approach to mathematical modelling to improve both the sensitivity and specificity of clinical measurements over time.

Supplementary Materials

Supplementary figures for Trost et al. paper.

  1. Supplementary Figures

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.