Figure 1: (a) Temperature distribution in the hepatic lobule at different radial distance from the centre, as predicted in the model, that is, in the absence of UCP-2. (b) Effects of reduced hepatic blood flow rate on temperature at the centre of the lobule. In both diagrams, the solid line () denotes the case when heat production rate is constant. The dashed line () and the dotted line () represent cases with a temperature-sensitive heat production rate.