Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure
Figure 3
Mean UCP-2 and TRPv4 scores for human and rat liver. In rat liver ((a) and (b) manual scores; mean ± s.e.m., ) and in human liver ((c) and (d); ±s.e.m., ). (e) and (f) show area fraction (%) UCP-2 and TRPv4 of immunostaining measured on automated histomorphometry in rat liver (mean and 95% CI, ). Pairwise -tests showed that the increases seen in central zones compared to either mid- or peri-portal zones on manual scoring in both rat and human liver were highly significant (), confirmed by significant reductions in % immunostaining in rat liver in mid and portal as compared to central zones on one-way ANOVA ( for UCP-2 and .001 for TRPv4).
