Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model
Figure 3
(a) Effects of distribution density of rogue RyRs on global change in (, left image) and depolarization of membrane potential (, right image ) without any external stimulus in heart failure. (b) Dependence of and on . represents the time to reach the peak of global from the end of resting stage, and is the time to reach the peak of . For each , we simulated 10 times under the same conditions to get statistical results due to the randomness of opening of RyR channels. The values denoted by arrows in (a) and (b) are recorded when = 0 pA. (c) Three groups of simulation results of when = 0.25, 1.0, and 1.75 rogue RyR/m2 (blue, red, and black curves, resp.). The inset is the enlarged view of depolarization of membrane potential during the period of ms. is also set to be 0 pA when = 1.75 rogue RyR/m2.
