Computational and Mathematical Methods in Medicine / 2012 / Article / Fig 1


Functional Dynamics of Proteins

Figure 1

Induced fit versus conformational selection. Protein (in cyan) exists preexisting conformers and “selects” a given conformer by stabilizing it with the incoming ligand (in blue). ENM reveals such transition via its low-frequency normal modes. KNF, Koshland-Néméthy-Filmer; MWC, Monod-Wyman-Changeux.

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