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Computational and Mathematical Methods in Medicine
Volume 2012, Article ID 320698, 7 pages
http://dx.doi.org/10.1155/2012/320698
Research Article

A Novel Weighted Support Vector Machine Based on Particle Swarm Optimization for Gene Selection and Tumor Classification

1Department of Computer Sciences, Faculty of Mathematical Sciences, Tarbiat Modares University, P.O. Box 14115-134, Tehran, Iran
2Department of Applied Mathematics, Sahand University of Technology, Tabriz, Iran

Received 14 February 2012; Revised 12 May 2012; Accepted 15 May 2012

Academic Editor: Dongsheng Che

Copyright © 2012 Mohammad Javad Abdi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We develop a detection model based on support vector machines (SVMs) and particle swarm optimization (PSO) for gene selection and tumor classification problems. The proposed model consists of two stages: first, the well-known minimum redundancy-maximum relevance (mRMR) method is applied to preselect genes that have the highest relevance with the target class and are maximally dissimilar to each other. Then, PSO is proposed to form a novel weighted SVM (WSVM) to classify samples. In this WSVM, PSO not only discards redundant genes, but also especially takes into account the degree of importance of each gene and assigns diverse weights to the different genes. We also use PSO to find appropriate kernel parameters since the choice of gene weights influences the optimal kernel parameters and vice versa. Experimental results show that the proposed mRMR-PSO-WSVM model achieves highest classification accuracy on two popular leukemia and colon gene expression datasets obtained from DNA microarrays. Therefore, we can conclude that our proposed method is very promising compared to the previously reported results.