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Computational and Mathematical Methods in Medicine
Volume 2012 (2012), Article ID 383546, 6 pages
Research Article

Simulation of Spread and Control of Lesions in Brain

CSIR Centre for Mathematical Modelling and Computer Simulation (C-MMACS), Bangalore 560017, India

Received 19 September 2011; Accepted 25 October 2011

Academic Editor: Vikas Rai

Copyright © 2012 Krishna Mohan Thamattoor Raman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Kantarci and D. Wingerchuk, “Epidemiology and natural history of multiple sclerosis: new insights,” Current Opinion in Neurology, vol. 19, no. 3, pp. 248–254, 2006. View at Publisher · View at Google Scholar
  2. T. J. Murray, “Diagnosis and treatment of multiple sclerosis,” British Medical Journal, vol. 332, no. 7540, pp. 525–527, 2006. View at Google Scholar
  3. M. Sospedra and R. Martin, “Immunology of multiple sclerosis,” Annual Review of Immunology, vol. 23, pp. 683–747, 2005. View at Publisher · View at Google Scholar
  4. V. H. Perry and D. C. Anthony, “Axon damage and repair in multiple sclerosis,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 354, no. 1390, pp. 1641–1647, 1999. View at Google Scholar
  5. F. M. Burnet and F. Fenner, The Production of Antibodies, MacMillan, Melbourne, VIC, Australia, 2nd edition, 1949.
  6. F. M. Burnet, Ed., Immunology: Readings from Scientific American, W. H. Freeman, San Francisco, Calif, USA, 1976.
  7. E. Christ and A. I. Tauber, “Selfhood, immunity, and the biological imagination: the thought of Frank Macfarlane Burnet,” Biology and Philosophy, vol. 15, pp. 509–533, 1999. View at Google Scholar
  8. G. J. V. Nossal, Antibodies and Immunity, Basic Books, New York, NY, USA, 2nd edition, 1978.
  9. O. A. Smirnova and N. V. Stepanova, “Mathematical model of autoimmunity,” Biofizika, vol. 20, no. 6, pp. 1095–1098, 1975. View at Google Scholar · View at Scopus
  10. P. Matzinger, “Tolerance, danger, and the extended family,” Annual Review of Immunology, vol. 12, pp. 991–1045, 1994. View at Google Scholar
  11. P. Matzinger, “An innate sense of danger,” Seminars in Immunology, vol. 10, no. 5, pp. 399–415, 1998. View at Publisher · View at Google Scholar
  12. U. Nevo, J. Kipnis, I. Golding et al., “Autoimmunity as a special case of immunity: removing threats from within,” Trends in Molecular Medicine, vol. 9, no. 3, pp. 88–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. U. Nevo, I. Golding, A. U. Neumann, M. Schwartz, and S. Akselrod, “Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity,” Journal of Theoretical Biology, vol. 227, no. 4, pp. 583–592, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Moalem, R. Leibowitz-Amit, E. Yoles, F. Mor, I. R. Cohen, and M. Schwartz, “Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy,” Nature Medicine, vol. 5, no. 1, pp. 49–55, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. T. R. Krishna Mohan, S. Sen, and M. Ramanathan, “A computational model for lesion dynamics in multiple sclerosis of the brain,” International Journal of Modern Physics E, vol. 17, no. 5, pp. 930–939, 2008. View at Publisher · View at Google Scholar
  16. T. R. Krishna Mohan, “Unpublished results”.