Identification and Functional Annotation of Genome-Wide ER-Regulated Genes in Breast Cancer Based on ChIP-Seq Data

Table 6

KEGG pathways enriched with the nearest-neighbor genes of ER binding sites (𝑃-value < 0.01).

KEGG ID	Pathways name	𝑃-value	Number of genes	Number of different expressed genes
hsa05200	Pathways in cancer	2.24𝐸−05	22	16
hsa04510	Focal adhesion	0.0002	15	14
hsa04360	Axon guidance	0.0009	11	8
hsa04810	Regulation of actin cytoskeleton	0.0012	14	11
hsa04010	MAPK signaling pathway	0.0022	15	12
hsa04114	Oocyte meiosis	0.0024	9	8
hsa04144	Endocytosis	0.0024	12	11
hsa04115	p53 signaling pathway	0.0024	7	7
hsa05216	Thyroid cancer	0.0024	5	4
hsa05218	Melanoma	0.0033	7	3
hsa04020	Calcium signaling pathway	0.004	11	4
hsa04062	Chemokine signaling pathway	0.0064	11	9
hsa04914	Progesterone-mediated oocyte maturation	0.0085	7	7
hsa01100	Metabolic pathways	0.0086	35	28
hsa00450	Selenoamino acid metabolism	0.0088	4	3
hsa05414	Dilated cardiomyopathy	0.0096	7	7
hsa03440	Homologous recombination	0.0097	4	3