Computational and Mathematical Methods in Medicine / 2012 / Article / Fig 1

Research Article

Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting

Figure 1

Schematic diagram of the patient compartments. CDAD = clostridium difficile-associated disease; CDAD+ = clostridium difficile-associated disease positive; CDAD− = clostridium difficile-associated disease negative; VRE = vancomycin-resistant enterococci; VRE+ = vancomycin-resistant enterococci colonized; VRE− = vancomycin-resistant enterococci not colonized; AB− = off antibiotics; AB+ = on antibiotics; = CDAD−, uncolonized, off antibiotic: admission rate; = CDAD−, uncolonized, off antibiotic: average length of stay; = CDAD−, uncolonized, on antibiotic: admission rate; = CDAD−, uncolonized, on antibiotic: average length of stay; = CDAD−, uncolonized, on antibiotic: stop antibiotic; = CDAD−, uncolonized, off antibiotic: start antibiotic; = CDAD+, uncolonized, off antibiotic: transit to CDAD−; = fraction of AB patients that transit to CDAD+ and stop AB; = CDAD−, uncolonized, on antibiotic: transit to CDAD+; CDAD+, uncolonized, on antibiotic: transit to CDAD−; = average number of contacts between uncolonized CDAD− patients on antibiotic and HCW; = probability of colonization per contact between uncolonized CDAD+ patient on antibiotic and contaminated HCW; = average number of contacts between uncolonized CDAD+ patients on antibiotic and HCW; = probability of colonization per contact between uncolonized CDAD− patient on antibiotic and contaminated HCW; = hand washing compliance factor between 0 and 1; = CDAD+, colonized, off antibiotic: transit to CDAD−; = CDAD−, colonized, on antibiotic: transit to CDAD+; = CDAD+, colonized, on antibiotic: transit to CDAD−; = CDAD−, colonized, off antibiotic: admission rate; = CDAD−, colonized, on antibiotic: stop antibiotic; = CDAD−, colonized, on antibiotic: admission rate; = CDAD−, colonized, off antibiotic: start antibiotic; = CDAD−, colonized, on antibiotic: average length of stay; = CDAD−, colonized, off antibiotic: average length of stay.
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