Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting
Sensitivity analyses of the model parameters. Dashed lines: Scenario 1 (use of AB only); Solid lines: Scenario 2 (use of non-anti-microbial); Vertical line: baseline values; (a) Percentage of CDAD+ patients that stop AB and start non-AB (baseline = 50%, ); (b) Number of colonized patients admitted per day in the ratio / = 2/3 (baseline = 0.33, = 0.5); (c) Length of stay of colonized patients in weeks (baseline = 4 weeks, = /= 1/28); (d) Hand-washing compliance percentage (baseline = 60%, ); (e) Percentage of uncolonized and colonized patients on AB (held equal) that become CDAD+ (baseline = 15%, = −log (0.9893)); (f) Time to symptoms resolution (TSR) of colonized CDAD+ patients on AB in days (baseline = 3.7 days, = −log (0.73)); AB = antibiotic; CDAD = clostridium difficile-associated disease; non-AB = nonantibiotic; = CDAD−, colonized, off antibiotic: admission rate; = CDAD−, colonized, on antibiotic: average length of stay; = CDAD−, uncolonized, on antibiotic: transit to CDAD+; = CDAD−, colonized, on antibiotic: transit to CDAD+; = CDAD−, colonized, off antibiotic: average length of stay; = CDAD−, colonized, on antibiotic: admission rate.
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