Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain: Neurochemical State Dependence of Global and Local Topological Properties

Table 2

Differences in degree 𝑘 by VOI compared to vehicle network.

Brain region	VOI	Amphetamine	Fluoxetine	Nicotine
Prefrontal cortex	Cg	+	+++	+++
	mPFC	+	−−−	ns
Somatosensory; and motor cortex	M1	+++	+++	+++
	S1BF	+++	+++	+++
	S1FL	+++	+++	+++
Other cortex	ctxV	−−−	+++	+++
	Ins	+++	ns	ns
	PtA	ns	+	+++
Hippocampus	hcAD	−−−	−−−	ns
	hcS	− −	ns	ns
	hcV	−−−	ns	−
Striatum	CPu	ns	+++	−−−
Thalamus	thalDL	−−−	+++	−−−
	thalMD	−−−	++	ns
	thalVM	ns	ns	ns

“+” signs indicate significantly greater 𝑘 compared to vehicle while “−” signs reflect significantly lower k, determined in each case using Bonferroni-corrected Mann-Whitney tests: + or − indicates 𝑃_𝑐<0.05, ++ or −− indicates 𝑃_𝑐<0.01, and +++ or −−− indicates 𝑃_𝑐<0.001 (Abbreviations: Cg: cingulate cortex; mPFC: medial prefrontal cortex (prelimbic and infralimbic regions combined); M1: primary motor cortex; S1BF: barrel field of primary somatosensory cortex; S1FL: forelimb field of primary somatosensory cortex, ctxV: visual cortex; Ins: insular cortex; PtA: parietal cortex; hcAD: anterodorsal hippocampus; hcS: subiculum region of hippocampus; hcV: ventral hippocampus; CPu: caudate putamen; thalDL: dorsolateral thalamus; thalMD: mediodorsal thalamus; thalVM: ventromedial thalamus.)