Myosin-V ATP cycle. (a) Both myosins bind ADP and are attached to actin (creating some bending strain from the relaxed “leg” positions shown in light grey). (b) With loss of ADP in the left leg, the power stroke can progress in the right leg. (c) On ATP binding, the left leg is released from actin and swings to the right and with ATP hydrolysis, it to returns to the pre-powerstroke conformation. (Reproduced from [1], with permission).
