Research Article

Discrete-State Stochastic Models of Calcium-Regulated Calcium Influx and Subspace Dynamics Are Not Well-Approximated by ODEs That Neglect Concentration Fluctuations

Figure 4

Subspace volume-dependence of calcium fluctuations and open probability of a calcium-activated channel. Steady-state probability distribution for = (a) and (b) for the calcium-activated channel ( μM, μM−2 ms−1) [29, 30]. (c) Steady-state and for integer multiples of the unitary volume and different rate constants for calcium binding (0.005 to 0.15 μM−2 ms−1) with fixed.