Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
Figure 7
Normalized cell volume (cell volume after loading/cell volume before loading) as a function of the PCM (a) collagen fibril modulus, (b) fixed charge density, and (c) fluid fraction in the models with four different ECM collagen fibril modulus values (Table 2, parametric PCM models 1–4). Other model parameters are as in the reference model. In all models, the strain was kept constant (ε = 16%). Above the horizontal line (- -) the cell volume is increased and under the line the cell volume is decreased. Vertical line (- -) in (b) represents the fixed charge density of the cell in the superficial zone.
