Computational and Mathematical Methods in Medicine

Research Article

The Number of Candidate Variants in Exome Sequencing for Mendelian Disease under No Genetic Heterogeneity

Table 4

The expected number of SNVs after filtering in dominant disease using full-sibs.



	/: 100%	/: 90%	/: 80%	/: 100% () 0% ()	/: 100% () 0% ()	/: ≥80% () 0% ()	/: ≥80% () 0% ()	/: ≥80% () ≤20% ()

1	19999.50	—	—	—	—	—	—	—
2	15832.94	—	—	4166.56	4166.56	—	—	—
3	13541.33	—	—	—	2291.61	—	—	—
4	12239.28	—	—	989.56	1302.05	—	—	—
5	11471.07	—	15312.12	—	768.21	—	—	—
10	10263.05	11227.51	13064.81	14.05	96.45	—	—	512.68
11	10193.97	—	—	—	69.08	948.55	—	—
13	10106.96	—	—	—	36.82	—	127.64	—
20	10013.86	10408.02	11922.23	0.01	4.71	—	—	40.85
21	10010.33	—	—	—	3.53	500.32	—	—
23	10005.70	—	—	—	1.98	—	38.66	—
50	9999.75	10031.07	11165.22	—	0.00	—	—	0.06
51	9999.75	—	—	—	—	291.41	—	—
53	9999.75	—	—	—	—	—	18.23	—
100	9999.75	10000.36	10661.20	—	—	—	—	—