Power Analysis of C-TDT for Small Sample Size Genome-Wide Association Studies by the Joint Use of Case-Parent Trios and Pairs

Table 4

Power and estimated probability of type I error for C-TDT across different sample sizes when 1% of the SNPs are generated under 𝐻₁.

Family group type		Power (%)	Estimated probability of type I error (%)
Case-parent trio size	Case-parent pair size
10	4	61.8	14.4
30	18	91.3	8.9
50	30	98.6	7.8
70	40	99.8	7.3
90	55	100.0	6.9
110	65	100.0	6.7
130	75	100.0	6.6