Power Analysis of C-TDT for Small Sample Size Genome-Wide Association Studies by the Joint Use of Case-Parent Trios and Pairs

Table 5

Power and estimated probability of type I error for C-TDT across different sample sizes when 2% of the SNPs are generated under 𝐻₁.

Family group type		Power (%)	Estimated probability of type I error (%)
Case-parent trio size	Case-parent pair size
10	4	41.3	14.4
30	18	66.1	8.9
50	30	83	7.8
70	40	92	7.3
90	55	96.5	6.9
110	65	98.5	6.7
130	75	99.4	6.6