Research Article

SNP Selection in Genome-Wide Association Studies via Penalized Support Vector Machine with MAX Test

Table 2

The result of simulations with 100 replications: selected SNPs and prognostic SNPs indicate the averaged numbers of the selected SNPs and the selected prognostic SNPs, respectively, in the fitted models; standard error is reported in the parentheses.

Genetic model Selected SNPs Prognostic SNPs Misclassification error
Enet SCAD Enet SCAD Enet SCAD

0Proposed43.10 48.66 20.31 5.11 5.46 3.31 0.1766 0.1567 0.2736
(0.54) (0.70)(0.65) (0.09) (0.07) (0.14) (0.0048) (0.0054)(0.0062)
Recessive40.50 41.38 25.28 4.62 4.74 3.66 0.2408 0.2518 0.2912
(0.56) (1.11)(0.66) (0.10) (0.10) (0.14) (0.0054) (0.0065)(0.0047)
Additive42.71 45.58 24.12 5.23 5.35 4.07 0.2161 0.2118 0.3272
(0.49) (0.87)(0.91) (0.08) (0.08) (0.18) (0.0048) (0.0064)(0.0076)
Dominant41.35 43.46 23.99 4.70 4.86 3.38 0.2457 0.2347 0.2995
(0.58) (0.98)(0.70) (0.10) (0.09) (0.12) (0.0056) (0.0063)(0.0042)

0.3Proposed42.92 45.68 19.56 5.12 5.20 3.40 0.1690 0.1541 0.2833
(0.50) (0.80)(0.48) (0.08) (0.08) (0.10) (0.0049) (0.0047)(0.0060)
Recessive39.49 41.09 27.23 4.34 4.47 3.03 0.2383 0.2368 0.2741
(0.58) (0.87)(0.59) (0.10) (0.11) (0.03) (0.0057) (0.0057)(0.0019)
Additive42.07 43.90 21.89 5.06 5.04 3.74 0.2126 0.2074 0.3338
(0.52) (0.96)(0.67) (0.08) (0.08) (0.08) (0.0052) (0.0057)(0.0056)
Dominant39.97 38.56 24.97 4.56 4.29 2.04 0.2502 0.23380.2607
(0.62) (1.03)(0.53) (0.10) (0.11) (0.03) (0.0065) (0.0059)(0.0039)