Comparison of Simple Models of Periodic Protocols for Combined Anticancer Therapy

Table 4

Proposed parameters.

Model	Parameter	Description	Value and unit
	𝛽	Tumor growth parameter	0.192 day^−1
	𝛾	Endothelial stimulation parameter	5.85 day^−1
	𝜆	Endothelial inhibition parameter	0.00873 day^−1 mm^−2/3
	𝜇	Natural mortality of endothelial cells	0 day^−1
	𝜂	Anti-angiogenic killing parameter	0.01 mg^−1
	𝜉	Cytostatic killing parameter Cisplatin (for endothelial cells)	0.0013 m^2 mg^−1
Hahnfeldt et al. [12]	𝜓	Cytostatic killing parameter Cisplatin (for cancer cells)	0.004 m^2 mg^−1
	𝜉	Cytostatic killing parameter Oxaliplatin (for endothelial cells)	0.005 m^2 mg^−1
	𝜓	Cytostatic killing parameter Oxaliplatin (for cancer cells)	0.01 m^2 mg^−1
	𝜎	Cytostatic killing parameter Capecitabine (for cancer cells)	0.00008 m^2 mg^−1
	𝜄	Cytostatic killing parameter Capecitabine (for endothelial cells)	0.00002 m^2 mg^−1
	𝑢	Dose of angiogenic inhibitor	Depends on protocol
	𝑣	Dose of cytotoxic drug Cisplatin
	𝑧	Dose of cytotoxic drug Capecitabine