Exploratory Bioinformatics Study of lncRNAs in Alzheimer’s Disease mRNA Sequences with Application to Drug Development
Figure 10
The fractal dimension correlation of the TYROBP-Variants 1–4 and TREM2 CDSs versus mRNAs involved in Late-onset Alzheimer’s disease. (). Inclusion of APOE (2.0267, 2.0382) would appear at the uppermost right corner in contrast to TREM2 at the lowest left corner and would give , (adjusted ). For comparison, similar correlation analysis on the mouse and Bos taurus TYROBP, TREM2, and APOE would give values of 0.89 (), and 0.45 () respectively. GenBank information: human TYROBP has Gen-ID-7305, human TREM2 has Gen-ID-54209, mouse TYROP has Gen-ID-22177, mouse TREM2 has Gen-ID-83433, mouse APOE has Gen-ID-11816, Bos taurus TYROP has Gen-ID-282390, Bos taurus TREM2 has Gen-ID-506467, and Bos taurus APOE has Gen-ID-281004.
