Using State Variables to Model the Response of Tumour Cells to Radiation and Heat: A Novel Multi-Hit-Repair Approach
Comparison of two different concepts for describing cell killing or cell survival (schematic illustration). The left diagram (a) shows a correcting down approach (bending down principle by a term describing additional cell killing due to previously acquired sub-lethal lesions). To correct the curve to the observed linear-quadratic-linear shape and to include dose rate dependences, dose protraction factors (e.g., Lea-Catcheside dose protraction factor [1, 6]) have been proposed. The right diagram (b) illustrates a correcting up approach due to the repair of potentially lethal lesions. If the activation of repair will need a certain dose, low dose hypersensitivity (dashed curve) can be explained .